Premier League: Manchester United 4 v 1 Fulham (FT)
Manchester United will assess the fitness of Anthony Martial, Luke Shaw, Chris Smalling, Eric Bailly and Phil Jones, who are all nursing injuries.
Ashley Young is available following a one-match suspension but Victor Lindelof and Alexis Sanchez remain out.
Fulham pair Kevin McDonald and Floyd Ayite are expected to return from respective hamstring and groin injuries.
On-loan defender Timothy Fosu-Mensah is ineligible to face his parent club.
A defeat for the Red Devils would result in their lowest points tally after 16 matches of a Premier League campaign.
They could draw four straight Premier League matches for the first time since 1992.
United could also equal the club's longest winless run versus promoted opposition of four games.
They have made a league-high 46 changes to their starting line-up this season.
Jose Mourinho is aiming for a 50th Premier League win as United manager in his 92nd game. It took him 63 matches to earn 50 wins in his first spell at Chelsea, and 73 in his second spell.
United have conceded 10 Premier League goals at Old Trafford this season, already surpassing their total goals against at home in 2017-18.
They are winless in 10 Premier League away games, losing their last six in a row - their worst run for 12 years.
Fulham's tally of nine points after 15 league games is their joint-worst at this stage of a league season, level with 1993-94 in the third tier.
They have conceded 36 goals in 15 Premier League games this season - only Barnsley, with 40 in 1997-98, have conceded more at this stage.
The Cottagers could set a new club record of 20 top-flight fixtures without a clean sheet.
They have lost 19 of their last 20 matches against last season's top six, drawing the other.
Claudio Ranieri could become only the third manager to win a Premier League away game at Old Trafford with two different clubs, emulating Martin O'Neill and Rafael Benitez.
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